1,2-双(苄氧基)-4-溴苯合成路线 （共 9 条）
反应条件
N-bromosuccinmide in tetrachloromethane T=80°C; 1 h;
参考文献
Mee, Simon P. H.; Lee, Victor; Baldwin, Jack E.; Cowley, Andrew
Tetrahedron, 2004 , vol. 60, # 16 p. 3695 - 3712
反应条件
potassium carbonate in acetone Reflux;
参考文献
Bai, Minghui; Huang, Jing; Zheng, Xiaolong; Song, Zhibin; Tang, Miru; Mao, Wuxiang; Yuan, Libo; Wu, Jun; Weng, Xiaocheng; Zhou, Xiang
Journal of the American Chemical Society, 2010 , vol. 132, # 43 p. 15321 - 15327
反应条件
1: 87 percent / K2CO3 / acetone / 96 h / Heating 2: 89 percent / N-bromosuccinimide / CCl4 / 1 h / 80 °C View Scheme
参考文献
Smissman,E.E.; Borchardt,R.T.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 377 - 382
Full Text View citing articles Show Details
Pines; Karady; Sletzinger
The Journal of organic chemistry, 1968 , vol. 33, # 5 p. 1758 - 1761
反应条件
1: K2CO3 / acetone 2: NBS / CCl4 View Scheme
参考文献
Mee, Simon P. H.; Lee, Victor; Baldwin, Jack E.; Cowley, Andrew
Tetrahedron, 2004 , vol. 60, # 16 p. 3695 - 3712
反应条件
1.1: boron tribromide / dichloromethane / 0 °C / Inert atmosphere; Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 5 °C 2.2: 1820 h / 20 °C View Scheme
参考文献
Sharma, Pradeep K.; He, Min; Romanczyk Jr., Leo J.; Schroeter, Hagen
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 10 p. 605 - 612
反应条件
1: N,N-dimethyl-formamide / 18 h / Reflux 2: diisobutylaluminium hydride / toluene / 3.5 h / -78 °C 3: dichloromethane / 18 h / 20 °C 4: diisobutylaluminium hydride / toluene / 2 h / -78 °C 5: Montmorillonite K-10 / dichloromethane / 5 h / 20 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 7: AD-mix-α; methanesulfonamide / water; tert-butyl alcohol / 72 h / 0 °C 8: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C 9: pyridinium p-toluenesulfonate / dichloromethane / 4 h / 60 °C 10: methanol; potassium carbonate / dichloromethane / 18 h / 20 °C View Scheme
参考文献
Viton, Florian; Landreau, Cyrille; Rustidge, David; Little, Gill; Robert, Fabien; Williamson, Gary; Barron, Denis
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 371 - 374
反应条件
1: N,N-dimethyl-formamide / 18 h / Reflux 2: diisobutylaluminium hydride / toluene / 3.5 h / -78 °C View Scheme
参考文献
Viton, Florian; Landreau, Cyrille; Rustidge, David; Little, Gill; Robert, Fabien; Williamson, Gary; Barron, Denis
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 371 - 374
反应条件
1: N,N-dimethyl-formamide / 18 h / Reflux
2: diisobutylaluminium hydride / toluene / 3.5 h / -78 °C
3: dichloromethane / 18 h / 20 °C
View Scheme
参考文献
Viton, Florian; Landreau, Cyrille; Rustidge, David; Little, Gill; Robert, Fabien; Williamson, Gary; Barron, Denis
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 5-6 p. 371 - 374
反应条件
1: aq. HNO3 / acetic acid
2: NaOH / aq. ethanol
3: H2 / Pt
4: K2CO3 / Cu / dimethylformamide / Heating
5: (i) NaH, DMSO, (ii) /BRN= 605294/
6: H2 / Pd / methanol / 2844.3 Torr
View Scheme
参考文献
Lee,F.G.H. et al.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 387 - 392
