3-氟-1,2-二(羟基甲基)苯合成路线 （共 7 条）
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene T=0 - 20°C; 4.55 h; 2: With sodium hydroxide; water in tetrahydrofuran; toluene T=0 - 5°C; 0.216667 h; Product distribution / selectivity;
参考文献
Roche Palo Alto LLC
Patent: US2009/143589 A1, 2009 ;
Location in patent: Page/Page column 5 ;
US 20090143589 A1
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene T=0 - 5°C; 4.58333 h; 2: With sodium hydroxide; water in tetrahydrofuran; toluene T=0 - 5°C; 0.0833333 h; Product distribution / selectivity;
参考文献
Roche Palo Alto LLC
Patent: US2009/143589 A1, 2009 ;
Location in patent: Page/Page column 5-6 ;
US 20090143589 A1
参考文献
Guertin, Kevin Richard
Patent: US2002/82260 A1, 2002 ;
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene T=0 - 20°C; 3.16667 h; 2: With sodium hydroxide; water in tetrahydrofuran; toluene T=0 - 5°C; 0.216667 h; Product distribution / selectivity;
参考文献
Roche Palo Alto LLC
Patent: US2009/143589 A1, 2009 ;
Location in patent: Page/Page column 6 ;
US 20090143589 A1
反应条件
[Cp*Ir(6,6’-(OH)2bpy)(H2O)][OTf]2 in water 20 h; Inert atmosphereRefluxGreen chemistry; Overall yield = 89 percent;
参考文献
Fujita, Ken-Ichi; Ito, Wataru; Yamaguchi, Ryohei
ChemCatChem, 2014 , vol. 6, # 1 p. 109 - 112
反应条件
1: 48percent HBr / Heating
2: Na2S*9H2O / ethanol; H2O / Heating
View Scheme
参考文献
King, Geoff; Higgins, Simon J.
Journal of the Chemical Society, Chemical Communications, 1994 , # 7 p. 825 - 826
反应条件
hydrogen bromide
Heating;
参考文献
King, Geoff; Higgins, Simon J.
Journal of the Chemical Society, Chemical Communications, 1994 , # 7 p. 825 - 826
