(1R,2S,5R)-5-甲基-2-异丙基环己基甲酸合成路线 （共 9 条）
反应条件
jones' reagent in acetone T=20°C; 1 h;
参考文献
Spino, Claude; Gobdout, Cedrickx
Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12106 - 12107
反应条件
1: With magnesium; iodine in tetrahydrofuran 2: With hydrogenchloride in tetrahydrofuran; water Ice; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
GENENTECH, INC.
Patent: WO2005/2582 A2, 2005 ;
Location in patent: Page 45-46 ;
反应条件
toluene-4-sulfonic acid T=175°C; 32 h; Inert atmosphere;
参考文献
US2012/283469 A1, ;
Page/Page column 4 ;
反应条件
1: in tetrahydrofuran T=-80°C; 15 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Journal of Polymer Science, Part A: Polymer Chemistry, , vol. 48, # 6 p. 1441 - 1448
反应条件
T=175°C; 72 h; Inert atmosphere; Product distribution / selectivity;
参考文献
US2012/283469 A1, ;
Page/Page column 3-4 ;
反应条件
1: (-)-menthyl chloride With iodine; magnesium; ethylene dibromide in tetrahydrofuran Heating; 2: carbon dioxide in tetrahydrofuran Further stages.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 23 p. 2692 - 2698
反应条件
magnesium; ethylene dibromide 1) diethyl ether, 2 h, reflux, 2) 1/2 h; Yield given. Multistep reaction;
参考文献
Liebigs Annalen der Chemie, , p. 725 - 726
反应条件
1: 91 percent / Lucas-reagent 2: 1) Mg, 1,2-dibromoethane / 1) diethyl ether, 2 h, reflux, 2) 1/2 h View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 725 - 726
参考文献
Tetrahedron, , vol. 19, p. 2073 - 2078
Tetrahedron letters, , vol. 12, p. 1109 - 1111
Journal of the American Chemical Society, , vol. 62, p. 735,737
Polythem. collect. Rep. med. Fac. Palacky Univ., , vol. 11, p. 5
