1-((2R,4R,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-甲基嘧啶-2,4(1H,3H)-二酮合成路线 （共 5 条）
反应条件
recombinant Escherichia coli thymidine phosphorylase T=37°C; pH=6.5; aq. buffer; Kinetics;
参考文献
Panova, Natalya G.; Alexeev, Cyril S.; Polyakov, Konstantin M.; Gavryushov, Sergei A.; Kritzyn, Anatoliy M.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 12 p. 1211 - 1214
反应条件
1: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 2: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C 3: 1.28 g / aq. AcOH / 3 h / 25 °C View Scheme
参考文献
Kumar, Piyush; Ohkura, Kazue; Balzarini, Jan; De Clercq, Erik; Seki, Koh-Ichi; Wiebe, Leonard I.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 7 - 29
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=50°C; 4 h;
参考文献
Kumar, Piyush; Ohkura, Kazue; Balzarini, Jan; De Clercq, Erik; Seki, Koh-Ichi; Wiebe, Leonard I.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 7 - 29
反应条件
1: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 2: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C View Scheme
参考文献
Kumar, Piyush; Ohkura, Kazue; Balzarini, Jan; De Clercq, Erik; Seki, Koh-Ichi; Wiebe, Leonard I.
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 7 - 29
反应条件
pyridine; N-ethyl-N,N-diisopropylamine T=40°C; 3 h;
参考文献
Rosemeyer, Helmut; Seela, Frank
Helvetica Chimica Acta, 1991 , vol. 74, # 4 p. 748 - 760
