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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
160549-81-5
合成路线
（共 23 条）
259133-69-2
→
反应条件
160549-81-5
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate Catalytic hydrogenation; 24 h;
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
160465-63-4
→
反应条件
160549-81-5
反应条件
hydrogen; lithium carbonate; platinum(IV) oxide in ethanol
参考文献
Comins; Benjelloun
Tetrahedron Letters, 1994 , vol. 35, # 6 p. 829 - 932
→
反应条件
160549-81-5
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; 6 h;
参考文献
Bandara Herath; Dhammika Nanayakkara
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 129 - 136
24424-99-5
二碳酸二叔丁酯
→
反应条件
160549-81-5
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 7.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 8.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 9.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
675-20-7
2-氮己环酮
→
反应条件
160549-81-5
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 7.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 8.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 9.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
150521-32-7
(S)-2-甲酰基-1-哌啶甲酸叔丁酯
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反应条件
160549-81-5
反应条件
1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 2: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
85275-45-2
1-Boc-3-羟基哌啶
→
反应条件
160549-81-5
反应条件
1.1: 89 percent / NaH / tetrahydrofuran / 6 h / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 2.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 5.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 6.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 7.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
131667-57-7
N-Boc-3,4-二氢-2H-吡啶
→
反应条件
160549-81-5
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 3.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 4.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 5.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 6.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
86953-81-3
N-叔丁氧羰基-2-羟基哌啶
→
反应条件
160549-81-5
反应条件
1.1: 86 percent / p-TsOH / toluene / 0.33 h 2.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 2.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 5.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 6.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 7.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
85908-96-9
1-Boc-2-哌啶酮
→
反应条件
160549-81-5
反应条件
1.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 2.1: 86 percent / p-TsOH / toluene / 0.33 h 3.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 3.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 4.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 5.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 6.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C 7.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 8.1: 94 percent / H2 / Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Wilkinson; Stehle; Beak
Organic letters, 2000 , vol. 2, # 2 p. 155 - 158
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