potassium carbonate in methanol 8.5 h; Ambient temperature;

1: 85 percent / ethyldiisopropylamine / CH2Cl2 / 0.67 h / -78 - 20 °C 2: 88 percent / Pd(PPh3)2Cl2, Et3N / dimethylformamide / 1.5 h / 90 °C 3: 68 percent / K2CO3 / methanol / 8.5 h / Ambient temperature View Scheme

1: 88 percent / Pd(PPh3)2Cl2, Et3N / dimethylformamide / 1.5 h / 90 °C 2: 68 percent / K2CO3 / methanol / 8.5 h / Ambient temperature View Scheme

1: 58 percent / LiCl, HMPA / 1.5 h / 130 °C 2: 96 percent / NaBH4 / methanol / 0.17 h / 0 °C View Scheme

N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium chloride T=130°C; 1.5 h;