6-氯-4(3H)-喹唑啉酮合成路线 （共 15 条）
反应条件
acetic acid; diethylamine T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
acetic acid; diethylamine T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
methanimidamide monoacetate in 2-methoxy-ethanol 2 h; Heating;
参考文献
Stevenson, Thomas M.; Kazmierczak, Franciszek; Leonard, Nelson J.
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 616 - 620
反应条件
T=210°C; Cycloaddition; 0.25 h;
参考文献
Chao, Qi; Deng, Lynn; Shih, Hsiencheng; Leoni, Lorenzo M.; Genini, Davide; Carson, Dennis A.; Cottam, Howard B.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3860 - 3873
反应条件
zinc(II) chloride T=200°C; 5 h; sealed tube;
参考文献
Organic Letters, , vol. 11, # 6 p. 1193 - 1196
反应条件
1: diethyl ether; sulfuryl chloride 2: 180 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1303
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 545 - 548
反应条件
1: HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 20 °C 2: conc. HCl / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 3 p. 383 - 391
反应条件
1: 1.) hydroxymethylpolystyrene, triethylamine, DMAP; 2.) camphorsulphonic acid; 3.) Me3SiCl, NaI / 1.) CH2Cl2, 0-25 deg C, 2 h; 2.) dioxan, reflux, 72 h; 3.) MeCN, dioxan, 75 deg C, 18 h 2: aq. HCl / 2 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 5 p. 1045 - 1048
反应条件
chlorine; iron(III) chloride; acetic acid
参考文献
Huaxue Xuebao, , vol. 22, p. 335,336
Scientia Sinica (English Edition), , vol. 7, p. 1035,1036
