6,7-二羟基喹唑啉-4(3H)-酮合成路线 （共 5 条）
反应条件
1: With hydrogen bromide in water T=110°C; Reflux; 2: With ammonia in water pH=7.0 - 7.5;
参考文献
Natco Pharma Limited
Patent: US2009/306377 A1, 2009 ;
Location in patent: Page/Page column 5-6 ;
反应条件
hydrogen bromide in water T=110 - 140°C; 16 h;
参考文献
Esteve Química, S.A.
Patent: EP2348020 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
pyridine hydrochloride T=180°C; 4 h; Melt conditions;
参考文献
Harris, Craig S.; Hennequin, Laurent F.; Willerval, Olivier
Tetrahedron Letters, 2009 , vol. 50, # 14 p. 1600 - 1602
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 120 °C 1.2: 0.75 h / 0 - 40 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 30 °C 3.1: toluene; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C View Scheme
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 120 °C 1.2: 0.75 h / 0 - 40 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 30 °C 3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / 0 °C / Inert atmosphere 3.2: 15 h / 20 °C 3.3: 3 h / 20 °C View Scheme
参考文献
Esteve Química, S.A.
Patent: EP2348020 A1, 2011 ;
