1: HF*pyridine 2: TsOH / dioxane 3: NaOH / pyridine; methanol 4: DMAP / CH2Cl2 5: TBAF / tetrahydrofuran 6: Dowex-50 / methanol 7: NH4OH / 24 h / 55 °C View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: 1.) BCl₃, 2.) NaOH / 1.) CH₂Cl₂ <br />2: adenosine deaminase / 72 h / 37 &deg;C / phosphate buffer, pH 7-7.5<br />3: 1.) TMSCl, pyridine, 3.) NH₄OH<br />4: pyridine<br /> <br /> &nbsp;

<br /> &nbsp;