2,2-二(羟基甲基)-1,3-丙烷二醇1-硝酸盐合成路线 （共 10 条）
反应条件
silver nitrate in acetonitrile T=70°C; 24 h; Darkness;
参考文献
DSM IP ASSETS B.V.; Duval, Stephane; Kindermann, Maik
Patent: US2014/147529 A1, 2014 ;
Location in patent: Paragraph 0109; 0110; 0111 ;
反应条件
nitric acid in water; 1,2-dichloro-ethane T=5°C; 1 h;
参考文献
Korolev; Eremenko; Meshikhina; Aleksandrov; Konovalova; Lodygina
Russian Chemical Bulletin, 2003 , vol. 52, # 8 p. 1859 - 1863
反应条件
hydrazine hydrate in 1,4-dioxane; ethanol 2.5 h; Heating;
参考文献
Simecek,J.
Collection of Czechoslovak Chemical Communications, 1962 , vol. 27, p. 362 - 371
反应条件
hydrazine hydrate in 1,4-dioxane; ethanol; water 3.5 h;
参考文献
ISIS PHARMA GmbH
Patent: US6365611 B1, 2002 ;
Location in patent: Example 1-2 ;
反应条件
tetra-(n-butyl)ammonium iodide; cystine dihydrochloride in N,N-dimethyl-formamide T=20°C; Electrochemical reaction1.6 V, 1 electron per -ONO2 group consumed; Product distribution; Further Variations:ReagentsSolventsreduction potential, consumed electrons;
参考文献
Hess, Ulrich; Brosig; Koenig; Stoeter; Stalleicken
Pharmazie, 2002 , vol. 57, # 7 p. 460 - 464
参考文献
ISIS PHARMA GmbH
Patent: US6365611 B1, 2002 ;
Location in patent: Example 6 ;
反应条件
potassium hydroxide in ethanol 2 h; Heating;
参考文献
Russian Chemical Bulletin, , vol. 51, # 12 p. 2306 - 2307
反应条件
potassium hydroxide in ethanol
参考文献
Korolev; Eremenko; Meshikhina; Aleksandrov; Konovalova; Lodygina
Russian Chemical Bulletin, 2003 , vol. 52, # 8 p. 1859 - 1863
反应条件
potassium hydroxide in ethanol 2 h; Heating;
参考文献
Korolev; Eremenko; Meshikhina
Russian Chemical Bulletin, 2002 , vol. 51, # 12 p. 2306 - 2307
反应条件
1: 70 percent / KOH / ethanol
2: 97 percent / AcOH; HNO3; Ac2O / H2O; CHCl3 / -5 - 20 °C
View Scheme
参考文献
Korolev; Eremenko; Meshikhina; Aleksandrov; Konovalova; Lodygina
Russian Chemical Bulletin, 2003 , vol. 52, # 8 p. 1859 - 1863
