D-赤式-alpha-苯基-合成路线 (共 2 条)
反应条件
Stage #1: With (2S,3S)-2,3-dihydroxybutanedioic acid in ethanol T=20°C; 18 h; Resolution of racemate; Stage #2: in water pH=13; Product distribution / selectivity; Show Experimental Procedure
参考文献
CELGENE CORPORATION Patent: EP1082307 B1, 2005 ; Location in patent: Page/Page column 5-6 ;
反应条件
Stage #1: With potassium tert-butylate in toluene T=20 - 70°C; 5 - 16 h; Stage #2: With hydrogenchloride in water; toluene Product distribution / selectivity; Show Experimental Procedure
参考文献
CELGENE CORPORATION Patent: EP1082307 B1, 2005 ; Location in patent: Page/Page column 7-8 ;