5-(2-羟基乙基)-2-噻吩羧酸甲酯合成路线 （共 3 条）
反应条件
1: 99 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 18 h 2: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 1 h, 2.) THF, hexane, from -70 deg C to RT, 3 h 3: H2SO4 / 18 h / Heating View Scheme
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 1 h, 2.) THF, hexane, from -70 deg C to RT, 3 h 2: H2SO4 / 18 h / Heating View Scheme
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
反应条件
sulfuric acid 18 h; Heating; Yield given;
参考文献
Varney, Michael D.; Palmer, Cindy L.; Romines III, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2502 - 2524
