4-[[[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]甲基]苯甲醛合成路线 （共 14 条）
反应条件
oxygen; caesium carbonate; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in toluene T=100°C; Oxidation; 1 h;
参考文献
Lee; Chang
Tetrahedron Letters, 2000 , vol. 41, # 39 p. 7507 - 7510
反应条件
1H-imidazole in N,N-dimethyl-formamide T=0 - 20°C; 4 h; Inert atmosphere;
参考文献
Nabuurs, Rob J.A.; Kapoerchan, Varsha V.; Metaxas, Athanasios; De Jongh, Sanne; De Backer, Maaike; Welling, Mick M.; Jiskoot, Wim; Windhorst, Albert D.; Overkleeft, Hermen S.; Van Buchem, Mark A.; Overhand, Mark; Van Der Weerd, Louise
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2469 - 2481
反应条件
1: (4-bromo-benzyloxy)-tert-butyl-dimethyl-silane With n-butyllithium in tetrahydrofuran; hexane T=-70°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-70 - -5°C; 4 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN; BARDIOT, Dorothée; CARLENS, Gunter; DALLMEIER, Kai; KAPTEIN, Suzanne; McNAUGHTON, Michael; MARCHAND, Arnaud; NEYTS, Johan; SMETS, Wim
Patent: WO2013/45516 A1, 2013 ;
Location in patent: Page/Page column 180 ;
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating 3: 62 percent / O2; NaOAc*3H2O / (neocuproine)Pd(OAc)2 / H2O; dimethylsulfoxide / 4 h / 80 °C / 22502.3 Torr View Scheme
参考文献
Chen, Li; Tilley, Jefferson W.; Guthrie, Robert W.; Mennona, Francis; Huang, Tai-Nan; Kaplan, Gerry; Trilles, Richard; Miklowski, Dorota; Huby, Nicolas; Schwinge, Virginia; Wolitzky, Barry; Rowan, Karen
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 729 - 733
反应条件
1: 71 percent / DMAP; Et3N / acetonitrile / 0.75 h 2: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating 3: 62 percent / O2; NaOAc*3H2O / (neocuproine)Pd(OAc)2 / H2O; dimethylsulfoxide / 4 h / 80 °C / 22502.3 Torr View Scheme
参考文献
Eash; Pulia; Wieland; Mohan
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8399 - 8401
反应条件
1: 71 percent / LiAlH4 / diethyl ether / 2 h / Heating 2: 62 percent / O2; NaOAc*3H2O / (neocuproine)Pd(OAc)2 / H2O; dimethylsulfoxide / 4 h / 80 °C / 22502.3 Torr View Scheme
参考文献
Chen, Li; Tilley, Jefferson W.; Guthrie, Robert W.; Mennona, Francis; Huang, Tai-Nan; Kaplan, Gerry; Trilles, Richard; Miklowski, Dorota; Huby, Nicolas; Schwinge, Virginia; Wolitzky, Barry; Rowan, Karen
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 8 p. 729 - 733
反应条件
1: 70 percent / triethylamine; DMAP / CH2Cl2 / 4 h / 20 °C 2: 76 percent / BiNO3-5H2O / CH2Cl2 / 0.75 h / 20 °C View Scheme
参考文献
Eash; Pulia; Wieland; Mohan
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8399 - 8401
反应条件
1: imidazole / CH2Cl2 2: MnO2 / tetrahydrofuran / Heating View Scheme
参考文献
Motoshima, Kazunori; Ishikawa, Minoru; Hashimoto, Yuichi; Sugita, Kazuyuki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3156 - 3172
反应条件
1.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 12 h / 0 - 20 °C / |Inert atmosphere 2.1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C / |Inert atmosphere 2.2: 24 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Nabuurs, Rob J.A.; Kapoerchan, Varsha V.; Metaxas, Athanasios; De Jongh, Sanne; De Backer, Maaike; Welling, Mick M.; Jiskoot, Wim; Windhorst, Albert D.; Overkleeft, Hermen S.; Van Buchem, Mark A.; Overhand, Mark; Van Der Weerd, Louise
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2469 - 2481
反应条件
1: LiAlH4 / diethyl ether / 1 h / 0 °C 2: 3M aq. HCl / tetrahydrofuran / 6 h / 25 °C 3: imidazole / acetonitrile / 8 h / 25 °C View Scheme
参考文献
Barluenga; Del Pozo; Olano
Synthesis, 1995 , # 12 p. 1529 - 1533
