反应条件
1: 1.) aluminum chloride / 1.) 1,2-dichloroethane, 20 min, 2.) 1,2-dichloroethane, 50 deg C, 1 h 2: dimethylformamide / 2 h / 60 °C 3: NaBH4 / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h 4: 94.5 percent / pyridine / Ambient temperature 5: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature 6: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature 7: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF4, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h 8: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C 9: 35percent hydrogen peroxide / dimethylsulfoxide / 0.25 h / 15 °C 10: 91 percent / manganese(IV) oxide / tetrahydrofuran / 9 h / Ambient temperature 11: Pd/C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 6 p. 1009 - 1015
