5-氨基-4-乙氧羰基-1-苯基吡唑合成路线 （共 44 条）
反应条件
1: acetonitrile / 8 h / Heating 2: cc HCl, SnCl2, / 24 h / 10 °C 3: 5 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 21, # 4 p. 291 - 295
反应条件
hydrazine hydrate 5 h; Heating;
参考文献
Wamhoff, Heinrich; Ertas, Muemtaz; Atta, Sanaa M. S.
Liebigs Annalen der Chemie, 1985 , # 9 p. 1910 - 1916
反应条件
sodium hydroxide in ethanol 2 h; Heating;
参考文献
Pathak, U. S.; Gandhi, Sudha; Rathod, I. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 8 p. 734 - 737
反应条件
phosphorus pentachloride; trichlorophosphate Behandeln des Reaktionsprodukts mit aethanol.NH3;
参考文献
Cheng; Robins
Journal of Organic Chemistry, 1956 , vol. 21, p. 1240,1242
反应条件
acetic acid Clauson-Kass reaction; 3 h; Heating;
参考文献
Kopp; Lancelot; Dallemagne; Rault
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1045 - 1050
反应条件
in acetic acid T=80°C; 1 h;
参考文献
Farghaly; Vanelle; El-Kashef
Heterocyclic Communications, 2005 , vol. 11, # 3-4 p. 255 - 262
反应条件
1: With hydrogenchloride; water Reflux; 2: With ammonium hydroxide in water
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 48 ;
反应条件
isopentyl nitrite in tetrahydrofuran 16 h; Heating;
参考文献
Beck, James R.; Gajewski, Robert P.; Lynch, Michael P.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 267 - 270
反应条件
hydrogenchloride; sodium nitrite; sulfur dioxide 1) < 10 deg C, 10 min, 2) CCl4, room temp., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Yamamoto, Susumu; Morimoto, Katsushi; Sato, Toshiaki
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1545 - 1547
