5-氨基-4-乙氧羰基-1-苯基吡唑合成路线 （共 44 条）
反应条件
in decalin
18 h; Reflux;
参考文献
Ghorab, Mostafa M.; Ragab, Fatma A.; Alqasoumi, Saleh I.; Alafeefy, Ahmed M.; Aboulmagd, Sarah A.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 171 - 178
反应条件
1: trichlorophosphate / |Cooling with ice; |Microwave irradiation
2: isopropyl alcohol / 0.83 h / |Microwave irradiation
View Scheme
参考文献
Jain, Kishor S.; Khedkar, Vijay M.; Arya, Nikhilesh; Rane, Prasad V.; Chaskar, Pratip K.; Coutinho, Evans C.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 166 - 175
反应条件
1: aqueous H2SO4
View Scheme
参考文献
CIBA
Patent: US2858309 , 1957 ;
反应条件
1: 65 percent / hydrazine monohydrate / ethanol / Heating
2: 88 percent / NaNO2; acetic acid / H2O / 0.5 h / 0 °C
3: 33 percent / xylene / Heating
4: H2 / Pd/C / methanol / 1.5 h / 20 °C
View Scheme
参考文献
Chien, Tun-Cheng; Smaldone, Ronald A.; Townsend, Leroy B.
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4105 - 4108
反应条件
1: 75 percent / NaOH / ethanol / 2 h / Heating
2: 70 percent / 2 h / Heating
3: 30 percent / 85percent N2H4*H2O / Heating
4: 88 percent / 2N HCl, NaNO2 / ethanol / 1 h
View Scheme
参考文献
Pathak, U. S.; Gandhi, Sudha; Rathod, I. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 8 p. 734 - 737
反应条件
1: 97 percent / acetic acid / 1 h / 80 °C
2: 76 percent / hydrazine hydrate / ethanol / 6 h / Heating
View Scheme
参考文献
Svetlik, Jan
Heterocycles, 1984 , vol. 22, # 11 p. 2513 - 2516
反应条件
1: 87 percent / acetic acid / Heating
2: 97 percent / 80percent hydrazine hydrate / ethanol / 5 h / Heating
3: 92 percent / NaN3, AcOH / 5 °C
4: 85 percent / Heating
5: 87 percent / NaOH / ethanol; H2O
View Scheme
参考文献
Svetlik, Jan
Heterocycles, 1984 , vol. 22, # 11 p. 2513 - 2516
反应条件
bromine in chloroform
参考文献
Eli Lilly and Company
Patent: US4620865 A1, 1986 ;
反应条件
bromine; isopentyl nitrite in chloroform
4 h; Ambient temperature;
参考文献
Beck, James R.; Gajewski, Robert P.; Lynch, Michael P.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 267 - 270
反应条件
nitrosyl chloride in chloroform
0.0833333 h; Heating;
参考文献
Beck, James R.; Gajewski, Robert P.; Lynch, Michael P.; Wright, Fred L.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 267 - 270
