1-Cbz-哌啶-4-甲酸乙酯合成路线 （共 14 条）
反应条件
sodium carbonate in dichloromethane T=0 - 20°C; 60 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/78750 A1, 2004 ;
Location in patent: Page 64 ;
WO 2004/078750 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
EP1553074 A1, ;
Page/Page column 47-48 ;
反应条件
triethylamine in tetrahydrofuran; water T=25°C; Carboxylation; 2 h;
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Tetrahedron Letters, , vol. 48, # 2 p. 199 - 202
反应条件
1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 2: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr 3: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 4: 93 percent / H2O; acetic acid / 105 °C View Scheme
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
1.1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 2.1: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr 3.1: 94 percent / sodium bicarbonate; potassium iodide / dimethylformamide / 50 - 68 °C 4.1: 93 percent / H2O; acetic acid / 105 °C 5.1: NaH / tetrahydrofuran / 0.5 h / 25 °C 5.2: t-BuLi / tetrahydrofuran / 0.92 h / -72 °C 5.3: 60 percent / tetrahydrofuran / 2.5 h / -72 °C View Scheme
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 5°C; 1 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
NEUROSEARCH A/S
Patent: WO2007/93603 A1, 2007 ;
Location in patent: Page/Page column 15 ;
WO 2007/093603 A1
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 0.5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14900 A1, 2004 ;
Location in patent: Page 48-49 ;
WO 2004/014900 A1
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2006/18727 A2, 2006 ;
Location in patent: Page/Page column 100 ;
WO 2006/018727 A2
反应条件
1: 73 percent / tetrahydrofuran / 0.83 h / -20 - 20 °C 2: 88 percent / acetic acid; hydrogen / Pd/C / ethanol / 2.5 h / 25 °C / 3102.89 Torr View Scheme
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
