2-(3-氰基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸乙酯合成路线 （共 28 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=75°C; 8 h;
参考文献
RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan
Patent: WO2012/14117 A1, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
1: ethyl-2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate With hydroxylamine hydrochloride in dimethyl sulfoxide T=40°C; 0.5 h; 2: With acetyl chloride in dimethyl sulfoxide T=70 - 80°C; 3: 2-methyl-1-bromopropane With potassium carbonate in dimethyl sulfoxide T=20 - 80°C;
参考文献
Vellanki, Siva Rama Prasad; Sahu, Arabinda; Raavi, Satyanarayana; Nuchu, Ravi; Dandala, Ramesh
Patent: US2013/303780 A1, 2013 ;
Location in patent: Paragraph 0042 ;
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=130 - 140°C; 16 h;
参考文献
NATCO PHARMA LIMITED; Kompella, Amala; Gampa, Venue Gopala Krishna; Adibhatla, Kali Satya Bhujanga Rao; Nannapaneni, Venkaiah Chowdary
Patent: US2013/172571 A1, 2013 ;
Location in patent: Paragraph 0101 ;
反应条件
t-Bu2(Cy)P; potassium hydrogencarbonate; 2-methyl propanoic acid; copper(I) bromide; palladium dichloride in toluene T=25°C; 21 h; Inert atmosphereReflux; Reagent/catalystTime;
参考文献
TEIJIN PHARMA LIMITED; Komiyama, Masato
Patent: US2013/158272 A1, 2013 ;
Location in patent: Paragraph 0310; 0311 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene T=70 - 75°C; 1 h;
参考文献
WO2011/73617 A1, ;
Page/Page column 27 ;
反应条件
hydroxylamine hydrochloride; sodium formate in formic acid 3 h; Reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; METSGER, Leonid; GOROHOVSKY, Sofia; KIPNIS, Noa; YURKOVSKI, Slavik
Patent: WO2011/31409 A1, 2011 ;
Location in patent: Page/Page column 17 ;
反应条件
t-Bu2(Cy)P; potassium carbonate; palladium dichloride in anhydrous xylene T=140°C; 24 h; Inert atmosphere; Reagent/catalyst;
参考文献
TEIJIN PHARMA LIMITED; Komiyama, Masato
Patent: US2013/158272 A1, 2013 ;
Location in patent: Paragraph 0316; 0317; 0318 ;
反应条件
1: ethanol / 0.25 h / 70 °C 2: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 60 °C 3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 1 h / 70 - 75 °C View Scheme
反应条件
in ethanol T=100°C; 2 h;
参考文献
Hasegawa, Masaichi
Heterocycles, 1998 , vol. 47, # 2 p. 857 - 864
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 70 °C 2: hydroxylamine hydrochloride; sodium formate / formic acid / 3 h / Reflux View Scheme
