2-(3-氰基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸乙酯合成路线 （共 28 条）
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 70 - 75 °C 2: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 140 - 145 °C 3: hydrogenchloride; ethanethioamide / isopropyl alcohol / 14 h / 40 - 45 °C 4: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C View Scheme
反应条件
1: palladium diacetate / dimethyl sulfoxide / 4 h / 40 - 45 °C 2: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C 3: hydrogenchloride; ethanethioamide / isopropyl alcohol / 14 h / 40 - 45 °C 4: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C View Scheme
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 75 - 80 °C 2.1: hydroxylamine hydrochloride; sodium formate / formic acid / 7 h / 99 - 100 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -45 - -40 °C 3.2: -20 °C 4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 1 h / 70 - 75 °C View Scheme
反应条件
1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 60 °C 2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 1 h / 70 - 75 °C View Scheme
反应条件
1.1: hydroxylamine hydrochloride; sodium formate / formic acid / 7 h / 99 - 100 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -45 - -40 °C 2.2: -20 °C 3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 1 h / 70 - 75 °C View Scheme
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -45 - -40 °C 1.2: -20 °C 2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 1 h / 70 - 75 °C View Scheme
反应条件
1: N-bromosuccinmide; trifluorormethanesulfonic acid / acetonitrile / -15 - 30 °C 2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 70 - 75 °C 3: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 140 - 145 °C 4: hydrogenchloride; ethanethioamide / isopropyl alcohol / 14 h / 40 - 45 °C 5: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C View Scheme
反应条件
1: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 140 - 145 °C 2: hydrogenchloride; ethanethioamide / isopropyl alcohol / 14 h / 40 - 45 °C 3: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C View Scheme
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C 1.2: 15 h / 0 - 20 °C 2.1: potassium carbonate / palladium diacetate; t-Bu2(Cy)P / xylene / 24.5 h / 20 °C / Reflux View Scheme
参考文献
US2011/313169 A1, ;
US 20110313169 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C 1.2: 15 h / 0 - 20 °C 2.1: potassium carbonate / palladium diacetate; t-Bu2(Cy)P / xylene / 5 h / 120 °C / Inert atmosphere View Scheme
参考文献
US2011/313169 A1, ;
US 20110313169 A1
