thionyl chloride 1.5 h; Heating / reflux;

polyphosphate ester in chloroform 16 h; Heating;

1: thionyl chloride / toluene; dimethylformamide / 3.5 h / Heating 2: concd. ammonium hydroxide / 1.) 0 deg C, 10 min, 2.) RT, 1h 3: 85 percent / polyphosphate ester / CHCl3 / 16 h / Heating View Scheme

1: concd. ammonium hydroxide / 1.) 0 deg C, 10 min, 2.) RT, 1h 2: 85 percent / polyphosphate ester / CHCl3 / 16 h / Heating View Scheme

1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=0 - 20°C; 2 h; 2: With zinc dibromide in tetrahydrofuran T=20°C; 2.75 h; 3: 5-bromo-1,3-benzenedicarbonitrile With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=50°C; 6 h;

potassium acetate; palladium diacetate in N,N-dimethyl-formamide T=85°C; 5 h;