4-羟基-2-(甲硫基)-6-(三氟甲基)嘧啶合成路线 （共 11 条）
反应条件
sodium hydroxide in water 1) RT, 3 h; 2) reflux, 5 min;
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
in tetrahydrofuran T=25°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 17 p. 4449 - 4452
反应条件
1: 70 percent / POCl3 / dimethylaniline 2: 60 percent / NH3 / methanol / 1) 0 deg C, 0.5 h; 2) -15 deg C, 4 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 79 percent / 10 percent HCl / 8 h / Heating 2: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 3: 47 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
hydrogen cation Elimination;
参考文献
Yagi, Kazuo; Akimoto, Kazuhiko; Mimori, Norihiko; Miyake, Toshiro; Kudo, Masaki; Arai, Kazutaka; Ishii, Shigeru
Pest Management Science, 2000 , vol. 56, # 1 p. 65 - 73
反应条件
1: 79 percent / 10 percent HCl / 8 h / Heating 2: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight 3: 20 percent / NH3 / diethyl ether / -5 to 0 deg C then -15 deg C, overnight View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
trichlorophosphate; 2,3-dimethyl aniline
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
1: 79 percent / 10 percent HCl / 8 h / Heating 2: 1) POCl3; 2) PCl5 / 1) reflux, overnight; 2) reflux, overnight View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
1: 70 percent / POCl3 / dimethylaniline
2: 98 percent / Na / Ambient temperature
View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
1: 91.5 percent / sulfuryl chloride / FeCl3 / acetic acid; acetic anhydride / Heating
2: 78 percent / POCl3 / dimethylaniline
View Scheme
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
