4-氯-2-甲硫基-6-三氟甲基嘧啶合成路线 （共 8 条）
反应条件
trichlorophosphate; 2,3-dimethyl aniline
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
反应条件
1: 87 percent / NaOH / H2O / 1) RT, 3 h; 2) reflux, 5 min 2: 70 percent / POCl3 / dimethylaniline View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
1: 68 percent / copper(I) iodide, KF, iododiazine / dimethylformamide / 10 h / 115 °C 2: 1.) n-BuLi, 2,2,6,6-tetramethylpiperidine, 2.) hexachloroethane / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 2 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 2 p. 551 - 556
反应条件
2,2,6,6-tetramethyl-piperidine; n-butyllithium; 1,2,2-trichloro-1,1,2-trichloro-ethane 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, -78 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 2 p. 551 - 556
反应条件
ammonia in methanol 1) 0 deg C, 0.5 h; 2) -15 deg C, 4 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 219 - 223
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 24 h; Heating / reflux;
参考文献
SmithKline Beecham Corporation
Patent: US6780869 B1, 2004 ;
Location in patent: Page column 11-12 ;
反应条件
1: 62 percent / ethanol / Ambient temperature; overnight 2: 63 percent / conc. HCl / 64 h / Heating 3: 46 percent / phosphorus oxychloride, N,N-dimethylaniline / 3 h / Heating View Scheme
参考文献
Gershon, Herman; Grefig, Anthony T.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1161 - 1167
反应条件
sodium
Ambient temperature;
参考文献
Gershon; Grefig; Scala
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 219 - 223
