(S)-N,N-二甲基-gamma-(1-萘基氧基)-2-噻吩丙胺磷酸盐合成路线 (共 4 条)
反应条件
1: With potassium hydroxide in diethylene glycol dimethyl ether T=120°C; 3 - 6 h; 2: With phosphoric acid in water; ethyl acetate 1.08333 - 1.25 h;
参考文献
US2007/167636 A1, ;
Page/Page column 4 ;
反应条件
phosphoric acid in mineral oil,with; hexane; water; dimethyl sulfoxide; ethyl acetate
反应条件
phosphoric acid in hexane; water; dimethyl sulfoxide; mineral oil
反应条件
hydrogenchloride; ammonium hydroxide; sodium hydroxide; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine in hexane; water; dimethyl sulfoxide; ethyl acetate; toluene
参考文献
Eli Lilly and Company
Patent: US5362886 A1, 1994 ;