(R)-Boc-beta-苯丙氨酸合成路线 （共 10 条）
反应条件
sodium carbonate in acetone T=0°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2755 - 2758
反应条件
1: 99 percent / (R)-N-3,5-(CF3Ph)2-thiourea-6'-MeO-chinchona alkaloid / acetone / 36 h / -60 °C 2: H2 / Pd/C / methanol / 10 h / 20 °C 3: toluene / 2 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 18 p. 6048 - 6049
反应条件
1: H2 / Pd/C / methanol / 10 h / 20 °C 2: toluene / 2 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 18 p. 6048 - 6049
反应条件
1.1: LDA / tetrahydrofuran / 1 h / -78 °C 1.2: 72 percent / tetrahydrofuran / 0.25 h / -78 °C 2.1: 80 percent / aq. (NH4)2Ce(NO3)6 / acetonitrile / 16 h / 0 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 39, # 6 p. 1063 - 1066
反应条件
1: 75 percent / Et3N / acetone; H2O / 2 h / 0 °C 2: penicillin G acylase/eupergit; aq. buffer / methanol / 20 °C / pH 7 3: 95 percent / aq. Na2CO3 / acetone / 2 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2755 - 2758
反应条件
1: penicillin G acylase/eupergit; aq. buffer / methanol / 20 °C / pH 7 2: 95 percent / aq. Na2CO3 / acetone / 2 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2755 - 2758
反应条件
1: AcONH4 / ethanol / 6 h / Heating 2: 75 percent / Et3N / acetone; H2O / 2 h / 0 °C 3: penicillin G acylase/eupergit; aq. buffer / methanol / 20 °C / pH 7 4: 95 percent / aq. Na2CO3 / acetone / 2 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2755 - 2758
反应条件
1.1: ammonium acetate / ethanol / 8 h / |Reflux 2.1: thionyl chloride / 2 h / |Reflux 2.2: |Reflux 3.1: trifluoroacetic acid / tetrahydrofuran / 0 °C / pH 8 - 9 3.2: 20 °C 4.1: Methylobacterium sp. Y1-6 / 8 h / 30 °C View Scheme
参考文献
Process Biochemistry, , vol. 48, # 11 p. 1674 - 1678
反应条件
1.1: thionyl chloride / 2 h / |Reflux 1.2: |Reflux 2.1: trifluoroacetic acid / tetrahydrofuran / 0 °C / pH 8 - 9 2.2: 20 °C 3.1: Methylobacterium sp. Y1-6 / 8 h / 30 °C View Scheme
参考文献
Process Biochemistry, , vol. 48, # 11 p. 1674 - 1678
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Inert atmosphere;
参考文献
Carocci, Alessia; Catalano, Alessia; Bruno, Claudio; Lentini, Giovanni; Franchini, Carlo; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte
Chirality, 2010 , vol. 22, # 3 p. 299 - 307
