反应条件
<b>Multi-step reaction with 7 steps<br /> </b>1.1: 175 g / acetic acid; H<sub>2</sub>O / 16 h / 60 °C<br />2.1: CH<sub>2</sub>Cl<sub>2</sub>; pyridine / 1 h / -15 °C<br />3.1: 179 g / CH<sub>2</sub>Cl<sub>2</sub>; pyridine / 20 h / -15 - 20 °C<br />4.1: NaOMe / methanol; tetrahydrofuran; CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 20 °C<br />4.2: 78 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 6 h / 0 - 20 °C<br />5.1: 3.70 g / NH<sub>4</sub>Cl; NaN<sub>3</sub> / dimethylformamide; H<sub>2</sub>O / 2 h / 80 °C<br />6.1: 3.84 g / n-tetrabutylammonium iodide; NaH / dimethylformamide / 2.5 h / 0 °C<br />7.1: 47 percent / 3 percent HCl / 18 h / 20 °C<br /> <br />
参考文献
Takahashi, Shunya; Kuzuhara, Hiroyoshi; Nakajima, Motowo Tetrahedron, 2001 , vol. 57, # 32 p. 6915 - 6926
