1.1: 21.7 g / Zn; AcOH / methanol / 1 h / sonication 2.1: i-PrMgCl; Ti(O-i-Pr)4 / diethyl ether / -78 - -50 °C 2.2: 51 percent / NBS / diethyl ether; tetrahydrofuran / -78 - 20 °C 3.1: 96 percent / imidazole / dimethylformamide / 12 h / 20 °C 4.1: DBU / toluene / 20 h / 70 °C 5.1: 1.16 g / Cs2CO3 / dimethylformamide / 12 h / 20 °C 6.1: aq. KOH; PdCl2(dppf) / tetrahydrofuran / 24 h / 60 °C 7.1: 68.3 mg / TBAF / tetrahydrofuran / 24 h / 20 °C View Scheme