1.1: 99 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 5 h / 20 °C 2.1: Mg / tetrahydrofuran / 20 °C 2.2: Li2CuCl4 / tetrahydrofuran / -78 °C 2.3: 55 percent / tetrahydrofuran / 17 h / -78 - 20 °C 3.1: 90 percent / pyridinium p-toluenesulfonate; ethanol / 3 h / 50 °C 4.1: 96 percent / N,N-(dimethylamino)pyridine / CH2Cl2 / 16 h 5.1: Mg / tetrahydrofuran / 20 °C 5.2: Li2CuCl4 / tetrahydrofuran / -78 °C 5.3: 64 percent / tetrahydrofuran / 15 h / -78 - 20 °C View Scheme
参考文献
Pinchuk, Anatoly N.; Rampy, Mark A.; Longino, Marc A.; Skinner, R. W. Scott; Gross, Milton D.; Weichert, Jamey P.; Counsell, Raymond E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2155 - 2165
triethyl borane; tri-n-butyl-tin hydride in hexane; toluene T=0°C; 0.5 h;
参考文献
Miura, Katsukiyo; Ichinose, Yoshifumi; Nozaki, Kyoko; Fugami, Keigo; Oshima, Koichiro; Utimoto, Kiitiro
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 143 - 147
1: sodium hydroxide / ethanol; benzene; water / 20 °C 2: triethylamine / dichloromethane / 0 - 20 °C / |Inert atmosphere 3: sodium hydroxide / water / 1 h / 90 °C 4: trifluoroacetic acid; tri-iso-propylsilane / dichloromethane / 4 h View Scheme
参考文献
Chou, Stanley S.; De, Mrinmoy; Kim, Jaemyung; Byun, Segi; Dykstra, Conner; Yu, Jin; Huang, Jiaxing; Dravid, Vinayak P.
Journal of the American Chemical Society, 2013 , vol. 135, # 12 p. 4584 - 4587
