1: With water in tetrahydrofuran; methanol T=0°C; Inert atmosphere; 2: With potassium carbonate in tetrahydrofuran; methanol T=40°C; 5 h; Inert atmosphere; 3: in tetrahydrofuran; methanol; water T=20°C; Inert atmosphere;

1.1: dichloromethane / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: dichloromethane / 0.5 h / Molecular sieve 2.2: 0 °C 3.1: water / tetrahydrofuran; methanol / 0 °C / Inert atmosphere 3.2: 5 h / 40 °C / Inert atmosphere 3.3: Amberlyst .(R). 15 H+ form / 20 °C / Inert atmosphere View Scheme

1.1: dichloromethane / 0.5 h / Molecular sieve 1.2: 0 °C 2.1: water / tetrahydrofuran; methanol / 0 °C / Inert atmosphere 2.2: 5 h / 40 °C / Inert atmosphere 2.3: Amberlyst .(R). 15 H+ form / 20 °C / Inert atmosphere View Scheme

sodium carbonate

Brij 58; pooled human liver microsomes; magnesium chloride in phosphate buffer T=37.5°C; pH=5.5; 4 h; Enzyme kinetics; Further Variations:pH-valuesTemperaturesSolventsincubation time; molar ratios;

human liver microsomes in phosphate buffer 1 h; Enzyme kinetics;

pyridine; diethyl ether; ethanol Reaktion ueber zwei Stufen;