(3S)-3-氨基丁酸叔丁酯合成路线 （共 7 条）
反应条件
hydrogen; palladium dihydroxide in methanol P=1551.44 Torr; 24 h;
参考文献
Fleck, Thomas J.; McWhorter Jr., William W.; DeKam, Richard N.; Pearlman, Bruce A.
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9612 - 9617
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1340756 A1, 2003 ;
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 87 percent / tetrahydrofuran; hexane / 3 h / -78 °C 2.1: 73 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Fleck, Thomas J.; McWhorter Jr., William W.; DeKam, Richard N.; Pearlman, Bruce A.
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9612 - 9617
反应条件
1: BuLi / tetrahydrofuran / -78 - 0 °C 2: H2 / Pd(OH)2/C / ethanol / 50 °C / 3800 Torr View Scheme
参考文献
Attwood, Michael R.; Conway, Elizabeth A.; Dunsdon, Rachel M.; Greening, John R.; Handa, Balraj K.; Jones, Philip S.; Jordan, Steven C.; Keech, Elizabeth; Wilson, Francis X.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 4 p. 429 - 432
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 93 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 87 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 73 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
参考文献
Davies, Stephen G.; Fenwick, David R.
Journal of the Chemical Society, Chemical Communications, 1995 , # 11 p. 1109 - 1110
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 15 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
