7-氧杂-3-氮杂双环[4.1.0]庚烷-3-羧酸叔丁酯合成路线 （共 15 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
Tetrahedron Letters, 2004 , vol. 45, # 37 p. 6841 - 6845
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 20°C; 3.25 h;
参考文献
ARRAY BIOPHARMA INC.
Patent: WO2009/140320 A1, 2009 ;
Location in patent: Page/Page column 77 ;
WO 2009/140320 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/117890 A2, 2005 ;
Location in patent: Page/Page column 103 ;
WO 2005/117890 A2
反应条件
triethylamine; 3-chloro-benzenecarboperoxoic acid in tetrahydrofuran; dichloromethane; water
参考文献
Robin, Aelig; Koehler, Valentin; Jones, Alison; Ali, Afruja; Kelly, Paul P.; O'Reilly, Elaine; Turner, Nicholas J.; Flitsch, Sabine L.
Beilstein Journal of Organic Chemistry, 2011 , vol. 7, art. no. 7, p. 1494 - 1498
反应条件
sodium hydrogencarbonate in dichloromethane; water 2 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6355640 B1, 2002 ;
Location in patent: Page column 33 ;
反应条件
1: CHCl3 / 12 h / 20 °C 2: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
反应条件
1: CHCl3 / 12 h / 20 °C 2: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
反应条件
1: 93 percent / benzene / 1 h / Heating 2: NH2NH2*H2O; KOH / ethane-1,2-diol / 1.5 h / Heating 3: CHCl3 / 12 h / 20 °C 4: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526
反应条件
1: NH2NH2*H2O; KOH / ethane-1,2-diol / 1.5 h / Heating 2: CHCl3 / 12 h / 20 °C 3: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526
反应条件
1: NaBH4 / ethanol / 6 h / 20 °C 2: 93 percent / benzene / 1 h / Heating 3: NH2NH2*H2O; KOH / ethane-1,2-diol / 1.5 h / Heating 4: CHCl3 / 12 h / 20 °C 5: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526
