7-氧杂-3-氮杂双环[4.1.0]庚烷-3-羧酸叔丁酯合成路线 （共 15 条）
反应条件
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 16 h / 80 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 16 h / 80 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 14 h / 0 - 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
反应条件
1: trimethylsilyl iodide / N,N-dimethyl-formamide / 20 °C / |Cooling with ice 2: pyridinium p-toluenesulfonate / dichloromethane / 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 27 h / 80 °C 4: hydrogenchloride / dichloromethane; ethyl acetate; methanol / 0 - 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
反应条件
1: trimethylsilyl iodide / N,N-dimethyl-formamide / 20 °C / |Cooling with ice 2: pyridinium p-toluenesulfonate / dichloromethane / 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 27 h / 80 °C 4: hydrogenchloride / dichloromethane; ethyl acetate; methanol / 0 - 20 °C 5: Dess-Martin periodane / dichloromethane / 2 h / 20 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; YI, Lei
Patent: WO2013/138210 A1, 2013 ;
反应条件
1: With copper(l) iodide in tetrahydrofuran T=-30 - 25°C; 16 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
WO2008/11130 A2, ;
Page/Page column 136-137 ;
WO 2008/011130 A2
