5-甲氧基-2-硝基苯胺合成路线 （共 40 条）
反应条件
1: With hydrogenchloride in water Heating / reflux; 2: With sodium hydroxide; sodium hydrogencarbonate in water
参考文献
Garst, Michael E.; Dolby, Lloyd Jay; Esfandiari, Shervin; MacKenzie, Vivian Rose; Avey JR., Alfred Arthur; Muchmore, David Charles; Cooper, Geoffrey Kenneth; Malone, Thomas C.
Patent: US2005/38076 A1, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
1: With diphenylphosphoranyl azide; triethylamine in tert-butyl alcohol 16 h; Heating / reflux; 2: With hydrogenchloride in methanol; water T=20°C; 96 h; 3: With potassium hydrogencarbonate in water 0.5 h;
参考文献
Auckland Uniservices Limited
Patent: EP1468688 A2, 2004 ;
Location in patent: Page/Page column 24; 47 ;
反应条件
sodium methylate in N-methyl-acetamide; methanol
参考文献
SANKYO COMPANY, LIMITED
Patent: US2003/8907 A1, 2003 ;
反应条件
sodium T=120°C; 4 h; In sealed tube;
参考文献
TargeGen, Inc.
Patent: US2005/245524 A1, 2005 ;
Location in patent: Page/Page column 90 ;
US 20050245524 A1
反应条件
hydrogenchloride in methanol T=20°C; 96 h;
参考文献
Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anderson, Robert F.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 169 - 182
反应条件
methoxylamine hydrochloride; potassium tert-butylate; copper(l) chloride in N,N-dimethyl-formamide T=20°C; Substitution; Amination;
参考文献
Seko, Shinzo; Miyake, Kunihito; Kavvamura, Norio
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 11 p. 1437 - 1444
反应条件
1: 91 percent / 2 M HCl, NaOAc / H2O / 0.33 h 2: 63 percent / HNO3, AcOH / acetic anhydride / 6 h / 25 - 40 °C 3: 85 percent / conc. HCl / 5 h / Heating View Scheme
参考文献
Synthesis, , # 3 p. 377 - 382
反应条件
in methanol T=80°C; 4 h;
参考文献
Sankyo Company, Limited
Patent: EP1191019 A1, 2002 ;
Location in patent: Page 58 ;
反应条件
silver nitrate; trifluoroacetic anhydride in ethanol; dichloromethane; chloroform
反应条件
2,4,6-trichlorosulfenamide; potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Journal of Organic Chemistry, , vol. 63, # 15 p. 4878 - 4888
