反应条件
1: 87.3 percent / triethylamine, ethyl bromoacetate / methanol / 92.5 h / Ambient temperature 2: 95.1 percent / NaH(50percent) / dimethylformamide / 4 h 3: 92.5 percent / titanium(III) chloride / methanol; H2O / 0.12 h / Ambient temperature 4: 1.) NaNO2, HCl (2N) 2.) CuCN, NaCN / 1.) water, 5 deg C, 20 min, 2.) water, room temp., 1 h; 94 deg C, 5 min 5: 91.8 percent / aq. NaOH (40percent) / methanol / 0.17 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 11 p. 3145 - 3157
