3-(2-苯基乙基)苯甲酸合成路线 （共 10 条）
反应条件
PPA T=170 - 180°C; Heating;
参考文献
Stanescu, Michaela Dina; Dinca, Nicolae; Sisu, Eugen
Revue Roumaine de Chimie, 2006 , vol. 51, # 7-8 p. 669 - 673
反应条件
1: With sodium hydroxide; ethanol; water
T=80°C; 0.5 h;
2: With hydrogenchloride; water in ethanol
T=20°C;
参考文献
Brady, Ryan M.; Vom, Amelia; Roy, Michael J.; Toovey, Nathan; Smith, Brian J.; Moss, Rebecca M.; Hatzis, Effie; Huang, David C. S.; Parisot, John P.; Yang, Hong; Street, Ian P.; Colman, Peter M.; Czabotar, Peter E.; Baell, Jonathan B.; Lessene, Guillaume
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1323 - 1343
反应条件
1: With sodium hydroxide; ethanol; water
T=75°C; 1 h;
2: With hydrogenchloride; water in ethanol
T=20°C;
参考文献
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
Patent: WO2006/2474 A1, 2006 ;
Location in patent: Page/Page column 188 ;
反应条件
1.1: KOt-Bu / tetrahydrofuran / 1 h / 80 °C
1.2: tetrahydrofuran / 0.5 h / 80 °C
2.1: H2 / 5percent Pd/C / ethanol; ethyl acetate / 0.67 h / 20 °C / 1875.19 Torr
3.1: aq. NaOH / methanol / 15 h / 20 °C
View Scheme
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
1.1: 2,4,6-trimethyl-pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.5 h / 20 °C / Cooling with acetonitrile-dry ice
2.1: iron (III) acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C
3.1: sodium hydroxide; ethanol; water / 0.5 h / 80 °C
3.2: 0 - 20 °C
View Scheme
参考文献
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
Patent: US2008/153802 A1, 2008 ;
反应条件
hydrogen iodide
6 h; Heating;
参考文献
Stanescu, Michaela Dina; Dinca, Nicolae; Sisu, Eugen
Revue Roumaine de Chimie, 2006 , vol. 51, # 7-8 p. 669 - 673
反应条件
1.1: iron (III) acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.25 h / 20 °C
2.1: sodium hydroxide; ethanol; water / 0.5 h / 80 °C
2.2: 0 - 20 °C
View Scheme
参考文献
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
Patent: US2008/153802 A1, 2008 ;
反应条件
1: iron (III) acetylacetonate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere
2: sodium hydroxide; water / ethanol / 0.5 h / 80 °C
View Scheme
参考文献
Brady, Ryan M.; Vom, Amelia; Roy, Michael J.; Toovey, Nathan; Smith, Brian J.; Moss, Rebecca M.; Hatzis, Effie; Huang, David C. S.; Parisot, John P.; Yang, Hong; Street, Ian P.; Colman, Peter M.; Czabotar, Peter E.; Baell, Jonathan B.; Lessene, Guillaume
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1323 - 1343
反应条件
[bis(acetoxy)iodo]benzene; potassium bromide in dichloromethane
T=40°C; 8 h;
参考文献
Dohi, Toshifumi; Takenaga, Naoko; Goto, Akihiro; Maruyama, Akinobu; Kita, Yasuyuki
Organic Letters, 2007 , vol. 9, # 16 p. 3129 - 3132
反应条件
[bis(acetoxy)iodo]benzene; potassium bromide in dichloromethane
T=40°C; 8 h;
参考文献
Dohi, Toshifumi; Takenaga, Naoko; Goto, Akihiro; Maruyama, Akinobu; Kita, Yasuyuki
Organic Letters, 2007 , vol. 9, # 16 p. 3129 - 3132
