3-[(2S)-2-吡咯烷基甲氧基]吡啶合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane 3 h; Ambient temperature;
参考文献
Abreo, Melwyn A.; Lin, Nan-Horng; Garvey, David S.; Gunn, David E.; Hettinger, Ann-Marie; Wasicak, James T.; Pavlik, Patricia A.; Martin, Yvonne C.; Donnelly-Roberts, Diana L.; Anderson, David J.; Sullivan, James P.; Williams, Michael; Arneric, Stephen P.; Holladay, Mark W.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 817 - 825
反应条件
1.1: 100 percent / pyridine / CH2Cl2 / 20 °C 2.1: NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C 2.2: 61 percent / tetrahydrofuran / 24 h / Heating 3.1: CF3CO2H / CH2Cl2 / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7637 - 7647
反应条件
1.1: NaH / tetrahydrofuran / 0.67 h / 0 - 20 °C 1.2: 61 percent / tetrahydrofuran / 24 h / Heating 2.1: CF3CO2H / CH2Cl2 / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7637 - 7647
反应条件
1: triphenylphosphine, DEAD 2: 31 percent / TFA / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 4 p. 817 - 825
