4-(4-甲基哌嗪)苯胺合成路线 （共 19 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; ethyl acetate T=20°C; P=2585.74 Torr; 8 h;
参考文献
Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269
反应条件
1: 92 percent / K2CO3 / dimethylsulfoxide / 8 h / 90 °C 2: 100 percent / H2 / Pd/C / ethyl acetate; methanol / 8 h / 20 °C / 2585.74 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 26 p. 8261 - 8269
反应条件
1: Cs2CO3 / 60 - 100 °C 2: H2 / Pd/C / methanol / 20 °C / 760 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1221 - 1227
反应条件
in N-methyl-acetamide
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;
反应条件
1: benzene 2: platinum; methanol / Hydrogenation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 14, p. 771,772
反应条件
1: 20 h / 100 °C / Sealed tube 2: hydrogen / palladium on activated charcoal / methanol / 24 h View Scheme
参考文献
WO2011/120025 A1, ;
WO 2011/120025 A1
反应条件
1: 140 °C 2: hydrazine hydrate / ethanol / 50 °C View Scheme
参考文献
WO2013/43232 A2, ;
WO 2013/043232 A2
反应条件
1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 90 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / 2585.81 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 2917 - 2929
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; Sealed tube;
参考文献
Olsson, Henric; Sjoe, Peter; Ersoy, Oguz; Kristoffersson, Anna; Larsson, Joakim; Norden, Bo
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 16 p. 4738 - 4740
反应条件
in ice-water; N,N-dimethyl-formamide
参考文献
Chen, Li; Ding, Qingjie; Gillespie, Paul; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoye; Perrotta, Agostino
Patent: US2002/151554 A1, 2002 ;
