1-甲基-4-(4-硝基苯基)哌嗪合成路线 (共 10 条)
反应条件
potassium carbonate in dimethyl sulfoxide T=90°C; 8 h;
参考文献
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Patent: WO2005/7625 A2, 2005 ;
Location in patent: Page 60-61 ;
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6762180 B1, 2004 ;
Location in patent: Page column 39 ;
US 6762180 B1
反应条件
formic acid in water T=120°C; 0.05 h; microwave irradiation;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 60-61 ;
反应条件
caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium diacetate in toluene T=90°C; Hartwig-Buchwald amination;
参考文献
Nguyen Thi, Hanh Thuy; Lee, Chong-Yew; Teruya, Kenta; Ong, Wei-Yi; Doh-ura, Katsumi; Go, Mei-Lin
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6737 - 6746
反应条件
1: in N,N-dimethyl-formamide T=80°C; 0.333333 h; 2: With N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 0.333333 h;
参考文献
Maclean, Derek; Zhu, Jiang; Chen, Mingying; Hale, Ron; Satymurthy, Nagichettiar; Barriot, Jorge R.
Journal of the American Chemical Society, 2003 , vol. 125, # 34 p. 10168 - 10169
参考文献
Journal of Organic Chemistry, , vol. 14, p. 771,772
反应条件
in N-methyl-acetamide
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; ethyl acetate T=20°C; P=2585.74 Torr; 8 h;
参考文献
Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Lenaerts, Anne J. M.; Lee, Richard E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 26 p. 8261 - 8269
反应条件
in N-methyl-acetamide
参考文献
Wurster, Siegfried; Engstrom, Mia; Savola, Juha-Matti; Hoglund, Iisa; Sallinen, Jukka; Haapalinna, Antti; Tauber, Andrei Yurievitch; Hoffren, Anna-Marja Katariina; Salo, Harri Elias
Patent: US2001/46991 A1, 2001 ;