(S)-N-缩水甘油邻苯二甲酰亚胺合成路线 （共 18 条）
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 3 h; Inert atmosphereReflux; stereospecific reaction;
参考文献
Green Chemistry, , vol. 12, # 8 p. 1380 - 1382
反应条件
in ethanol; water 27 h; Heating;
参考文献
Roehrig, Susanne; Straub, Alexander; Pohlmann, Jens; Lampe, Thomas; Pernerstorfer, Josef; Schlemmer, Karl-Heinz; Reinemer, Peter; Perzborn, Elisabeth
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5900 - 5908
反应条件
in methanol; water 20 h; Reflux;
参考文献
FARMAK, A.S.; URBASEK, Miroslav; HRADIL, Pavel; GREPL, Martin; FIALOVA, Petra; OREMUS, Vladimir; SLEZAR, Petr
Patent: WO2012/41263 A2, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
1: N,N-dimethyl-formamide 2: dichloromethane View Scheme
参考文献
Reddy, Pingili Krishna; Mukkanti; Rao, Dodda Mohan
Asian Journal of Chemistry, 2012 , vol. 24, # 8 p. 3479 - 3482
反应条件
in N,N-dimethyl-formamide
5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Reddy, Pingili Krishna; Mukkanti; Rao, Dodda Mohan
Asian Journal of Chemistry, 2012 , vol. 24, # 8 p. 3479 - 3482
反应条件
1: in tetrahydrofuran
21.5 h; Heating / reflux;
2: With di-isopropyl azodicarboxylate; triphenylphosphine
T=7 - 22°C; 24.75 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82835 A1, 2003 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: toluene / 5 h / 122 °C
2: 101.5 g / PPh3; DIAD / toluene; propan-1-ol
View Scheme
参考文献
Wilkinson, Mark C.; Bell, Rebecca; Landon, Robert; Nikiforov, Petar O.; Walker, Andrew J.
Synlett, 2006 , # 13 p. 2151 - 2153
反应条件
1: in tetrahydrofuran
21.5 h; Heating / reflux;
2: With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=3 - 22°C; 30.25 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/82863 A1, 2003 ;
Location in patent: Page/Page column 24-25 ;
WO 03/082863 A1
