1-[4-[(四氢-2H-吡喃-2-基)氧基]苯基]乙酮合成路线 （共 13 条）
反应条件
pyridinium p-toluenesulfonate in dichloromethane 1.5 h; Ambient temperature;
参考文献
Artico, Marino; Santo, Roberte Di; Costi, Roberta; Novellino, Ettore; Greco, Giovanni; Massa, Silvio; Tramontane, Enzo; Marongiu, Maria E.; De Montis, Antonella; Colla, Paolo La
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 3948 - 3960
反应条件
dihydrogen peroxide; tantalum pentachloride; sodium iodide in phosphate buffer; ethyl acetate T=20°C; pH=7.2; 0.5 h;
参考文献
Kirihara, Masayuki; Noguchi, Takuya; Okajima, Nobuhiro; Naito, Sayuri; Ishizuka, Yuki; Harano, Aiko; Tsukiji, Hiroyuki; Takizawa, Ryu
Tetrahedron, 2012 , vol. 68, # 5 p. 1515 - 1520
反应条件
pyridinium p-toluenesulfonate in dichloromethane T=20°C; Etherification; 4 h;
参考文献
Hsieh, Hsin-Kaw; Lee, Tai-Hua; Wang, Jih-Pyang; Wang, Jeh-Jeng; Lin, Chun-Nan
Pharmaceutical Research, 1998 , vol. 15, # 1 p. 39 - 46
反应条件
1: sodium hydroxide / ethanol / 20 °C 2: hydrogenchloride; water / ethanol View Scheme
参考文献
Kim, Seok-Ho; Lee, Eunyoung; Baek, Kyung Hye; Kwon, Han Byeol; Woo, Hyunjung; Lee, Eung-Seok; Kwon, Youngjoo; Na, Younghwa
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3320 - 3324
反应条件
iron(III) tosylate hexahydrate in methanol T=20°C; 1.83333 h;
参考文献
Bockman, Matthew R.; Angeles, Veronica V.; Martino, Julia M.; Vagadia, Purav P.; Mohan, Ram S.
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6939 - 6941
反应条件
1: Ba(OH)2*8H2O / ethanol / 24 h / 30 °C 2: aq. HCl / ethanol / 25 °C View Scheme
参考文献
Liu; Wilairat; Go
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4443 - 4452
反应条件
1: sodium hydroxide / ethanol / 12 h / 20 °C 2: hydrogenchloride; water / ethanol / 0.5 h / 20 °C 3: ethanol; water / 1.5 h / 210 °C / 30003 Torr / Microwave irradiation; Autoclave View Scheme
参考文献
Jeon, Jae-Ho; Kim, Mi Ran; Jun, Jong-Gab
Synthesis, 2011 , # 3 art. no. F18510SS, p. 370 - 376
反应条件
1: sodium hydroxide / ethanol / 6 h / 20 °C 2: Dowex 50X2 resin / methanol / 15 h / 20 °C View Scheme
参考文献
Kim, Si-Jun; Kim, Cheol Gi; Yun, So-Ra; Kim, Jin-Kyung; Jun, Jong-Gab
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 181 - 185
反应条件
Ba(OH)2*8H2O in methanol T=40°C; Condensation; 12 h; stirring; evapg.; water adding; neutralizing with 1 M HCl, extg. with EtOAc;
参考文献
Lin, Chun-Nan; Lee, Tai-Hua; Hsu, Mei-Feng; Wang, Jih-Pyang; Ko, Feng-Nien; Teng, Che-Ming
Journal of Pharmacy and Pharmacology, 1997 , vol. 49, # 5 p. 530 - 536
反应条件
1: Ba(OH)2*8H2O / ethanol / 24 h / 30 °C 2: aq. HCl / ethanol / 25 °C View Scheme
参考文献
Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909
