反应条件
1: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 2: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 3: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 4: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 5: 40 percent / t-BuOK / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 12 p. 3890 - 3901
