反应条件
1: 89 percent / 2-methyl-propan-2-ol / 90 h / Ambient temperature 2: 93 percent / NaHCO3 / acetonitrile / 21 h / 70 °C 3: HOAc, iPrOH, H2O / 15 h / 100 °C 4: PhPOCl2 / 0.25 h / 100 °C 5: 96 percent / LiAlH4 / tetrahydrofuran / 1.5 h / - 70 deg C up to r.t. 6: Et3N, SO3*pyridine / dimethylsulfoxide / 1 h / 20 °C 7: 1) potassium tert-butoxide / 1) THF, 10 deg C, 10 min, 2a) -78 up to -50 deg C, 1 h, 2b) -25 deg C, 30 min 8: methanol, HCl, acetyl chloride / 4 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 10 p. 3068 - 3074
