thiolacetic acid potassium salt in N,N-dimethyl-formamide T=100°C; 5.5 h;

1: 93 percent / DMAP; Et3N / tetrahydrofuran / 0.5 h / 5 °C 2: 88 percent / potassium thioacetate / dimethylformamide / 5.5 h / 100 °C View Scheme

1.1: KOH / propan-2-ol; methanol / 0.17 h / 5 °C 1.2: 87 percent / HCl / propan-2-ol; methanol / 15 h / 5 °C 2.1: 94 percent / diisopropyl ethylamine; MeCN / 2 h / -20 °C 3.1: 82 percent / sodium hydrogen carbonate / Pd-C / butan-1-ol; H2O / 1.5 h / 20 °C / 3000.24 Torr View Scheme