4-异丁氧基-1,3-苯二甲腈合成路线 （共 9 条）
反应条件
sodium carbonate; palladium diacetate in N,N-dimethyl-formamide T=140 - 145°C; 18 h;
参考文献
WO2011/141933 A2, ;
Page/Page column 44-45 ;
反应条件
1: para-nitro-benzonitrile With potassium cyanide in dimethyl sulfoxide T=100°C; 1 h; Heating; 2: 2-methyl-1-bromopropane With potassium carbonate T=80°C; 2 h;
参考文献
EP1471065 A1, ;
Page 5 ;
反应条件
potassium carbonate; potassium iodide in dimethyl sulfoxide T=70 - 75°C; 16 h; Product distribution / selectivity;
参考文献
WO2011/141933 A2, ;
Page/Page column 43 ;
反应条件
1: palladium diacetate / dimethyl sulfoxide / 4 h / 40 - 45 °C 2: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C View Scheme
反应条件
1: N-bromosuccinmide; trifluorormethanesulfonic acid / acetonitrile / -15 - 30 °C 2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 70 - 75 °C 3: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 140 - 145 °C View Scheme
反应条件
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 70 - 75 °C 2: sodium carbonate / palladium diacetate / N,N-dimethyl-formamide / 18 h / 140 - 145 °C View Scheme
反应条件
potassium carbonate 1.) DMSO, 100 deg C, 1 h, 2.) 6 h; 70 deg C; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 47, # 2 p. 857 - 864
反应条件
1: 85 percent / thioacetamide, HCl / dimethylformamide / 40 h / 45 °C 2: 306 mg / ethanol / 2 h / 100 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; VENKATA PANAKALA RAO, Gogulapati; PRASAD, Gadamsetty
Patent: WO2011/141933 A2, 2011 ;
反应条件
hydrogenchloride; ethanethioamide in N,N-dimethyl-formamide T=45°C; 40 h;
参考文献
Hasegawa, Masaichi
Heterocycles, 1998 , vol. 47, # 2 p. 857 - 864
