1: 89 percent / KMnO4 / pyridine; H2O / 1 h / Heating 2: oxalyl chloride, DMF / CH2Cl2 3: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight 4: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 5: sodium cyanoborohydride, acetic acid / methanol 6: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

1: oxalyl chloride, DMF / CH2Cl2 2: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight 3: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 4: sodium cyanoborohydride, acetic acid / methanol 5: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

1: 85 percent / aq. K2CO3, Pd(OAc)2 / acetone / 6 h / Heating 2: 89 percent / KMnO4 / pyridine; H2O / 1 h / Heating 3: oxalyl chloride, DMF / CH2Cl2 4: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight 5: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 6: sodium cyanoborohydride, acetic acid / methanol 7: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

1: 85 percent / aq. K2CO3, Pd(OAc)2 / acetone / 6 h / Heating 2: 89 percent / KMnO4 / pyridine; H2O / 1 h / Heating 3: oxalyl chloride, DMF / CH2Cl2 4: 1.) n-BuLi / 1.) hexane, RT, 5 min, 2.) THF, hexane, RT, overnight 5: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 6: sodium cyanoborohydride, acetic acid / methanol 7: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

1: H2 / 10percent Pd/C / tetrahydrofuran / 0.5 h / 2068.6 Torr 2: sodium cyanoborohydride, acetic acid / methanol 3: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

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triethylsilane; trifluoroacetic acid in dichloromethane 1 h; Ambient temperature;

1: sodium cyanoborohydride, acetic acid / methanol 2: TFA, triethylsilane / CH2Cl2 / 1 h / Ambient temperature View Scheme

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