(R)-2,6-二甲基-1,2,3,4-四氢喹啉合成路线 （共 4 条）
反应条件
(R)-(-)-5,5'-bis(diphenylphosphino)-2,2,2',2'-tetrafluoro-4,4'-bi-1,3-benzodioxole; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; hydrogen; iodine in tetrahydrofuran T=20°C; P=36201.3 Torr; 24 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Tianli; Zhuo, Lian-Gang; Li, Zhiwei; Chen, Fei; Ding, Ziyuan; He, Yanmei; Fan, Qing-Hua; Xiang, Junfeng; Yu, Zhi-Xiang; Chan, Albert S. C.
Journal of the American Chemical Society, 2011 , vol. 133, # 25 p. 9878 - 9891
反应条件
sodium tetrahydroborate; nickel dichloride in methanol 1 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Kim, Hung Lam; Xu, Lijin; Feng, Lichun; Fan, Qing-Hua; Fuk, Loi Lam; Lo, Wai-Hung; Chan, Albert S. C.
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 14 p. 1755 - 1758
反应条件
1: With [Ir(cycloocta-1,5-diene)2]tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; C26H17O3P; hydrogen in ethanol; dichloromethane T=50°C; P=41802.8 Torr; 6 h; 2: With sodium hydroxide in water; toluene T=20°C; 1 h; enantioselective reaction;
参考文献
Lyubimov, Sergey E.; Ozolin, Dmitry V.; Ivanov, Pavel Yu; Melman, Artem; Velezheva, Valeriya S.; Davankov, Vadim A.
Chirality, 2014 , vol. 26, # 1 p. 56 - 60
反应条件
1: 82 percent / "sulfomix" (nitrobenzene/oleum) / H2O / 105 to 125 deg C within 30 min, 2 h at 125 deg C 2: NaBH4/NiCl2*6H2O / methanol / 1 h / Ambient temperature View Scheme
参考文献
Reichardt, Christian; Harms, Klaus; Kinzel, Manuela; Schaefer, Gerhard; Stein, Joerg; Wocadlo, Sigrid
Liebigs Annalen, 1995 , # 2 p. 317 - 328
