2-(4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯合成路线 （共 8 条）
反应条件
1: 4-hydroxy-benzonitrile With sodium hydroxide; hydrogen sulfide in ethanol T=80°C; P=1551.49 - 3102.97 Torr; 2: With hydrogenchloride in ethanol pH=3.5; 3: ethyl 2-chloro-3-oxobutanoate in ethanol T=70°C; 2 - 3 h; Heating / reflux;
参考文献
Robbins, Timothy A.; Zhu, Helen; Shao, Jun
Patent: US2005/75503 A1, 2005 ;
Location in patent: Page/Page column 3 ;
反应条件
1: With boron tribromide in dichloromethane T=20°C; 2: With methanol in dichloromethane
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 14 ;
反应条件
in spirit T=60 - 65°C; 2.5 h;
参考文献
RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan
Patent: WO2012/14117 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
hydrogenchloride; sodium hydroxide in ethanol
参考文献
Robbins, Timothy A.; Zhu, Helen; Shao, Jun
Patent: US2005/27128 A1, 2005 ;
反应条件
1: methanesulfonic acid / 10 h / 75 °C 2: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C 3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 75 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2012/168948 A2, 2012 ;
反应条件
1: trifluoroacetic acid / 40 h / Reflux 2: potassium carbonate; N,N-dimethyl-formamide / 4 h / 87 - 93 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2012/168948 A2, 2012 ;
反应条件
methanesulfonic acid T=75°C; 10 h;
参考文献
RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan
Patent: WO2012/14117 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
1: methanesulfonic acid / 10 h / 75 °C 2: hydroxylamine hydrochloride; sodium formate; formic acid / 8 h / 100 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; CHATTERJEE, Pranab; NATH, Asok; SOKHI, Sarbjot Singh; PRASAD, Mohan
Patent: WO2012/14117 A1, 2012 ;
