methanesulfonic acid T=75°C; 10 h;

1: spirit / 2.5 h / 60 - 65 °C 2: methanesulfonic acid / 10 h / 75 °C View Scheme

1: spirit / 2.5 h / 60 - 65 °C 2: methanesulfonic acid / 10 h / 75 °C View Scheme

1: ethyl-2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate With hydroxylamine hydrochloride in dimethyl sulfoxide T=40°C; 0.5 h; 2: With acetyl chloride in dimethyl sulfoxide T=70 - 80°C; 3: 2-methyl-1-bromopropane With potassium carbonate in dimethyl sulfoxide T=20 - 80°C;

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 70 °C 2: hydroxylamine hydrochloride; sodium formate / formic acid / 3 h / Reflux View Scheme

potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=70°C; 4 h; Product distribution / selectivity;

1: With hydroxylamine hydrochloride in N,N-dimethyl-formamide 0.5 h; 2: With acetyl chloride in N,N-dimethyl-formamide T=90°C;