(R)-(+)-2-氨基-4-甲基-1,1-二苯基-1-戊醇合成路线 （共 3 条）
反应条件
in tetrahydrofuran T=0°C; 4 h;
参考文献
Andres; Martinez; Pedrosa; Perez-Encabo
Tetrahedron Asymmetry, 1994 , vol. 5, # 1 p. 57 - 66
反应条件
1: bromobenzene With magnesium in diethyl ether T=40°C; Inert atmosphere; 2: D-leucine methyl ester hydrochloride in diethyl ether T=0 - 20°C; 15.5 h;
参考文献
Berkessel, Albrecht; Harnying, Wacharee; Duangdee, Nongnaphat; Neudoerfl, Joerg-M.; Groeger, Harald
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 123 - 128
反应条件
1.1: thionyl chloride / 3 h / Reflux 2.1: magnesium / diethyl ether / 40 °C / Inert atmosphere 2.2: 15.5 h / 0 - 20 °C View Scheme
参考文献
Berkessel, Albrecht; Harnying, Wacharee; Duangdee, Nongnaphat; Neudoerfl, Joerg-M.; Groeger, Harald
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 123 - 128
