(5-苯基异噁唑-3-基)甲醇合成路线 （共 13 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 0.5 h;
参考文献
Pei; Wickhan
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7509 - 7512
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 0.5 h;
参考文献
VICURON PHARMACEUTICALS INC.
Patent: US2006/211603 A1, 2006 ;
Location in patent: Page/Page column 65 ;
反应条件
1: NH2OH*HCl / ethanol / 1 h / Heating 2: LiAlH4 / diethyl ether / 0.5 h / 40 °C View Scheme
参考文献
Synthesis, , # 15 p. 2325 - 2330
反应条件
sodium tetrahydroborate; isopropyl alcohol 4 h;
参考文献
Potkin; Petkevich; Kletskov; Dikusar; Zubenko; Zhukovskaya; Kazbanov; Pashkevich
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 10 p. 1523 - 1533
Zh. Org. Khim., 2013 , vol. 49, # 10 p. 1543 - 1553,11
反应条件
1.1: NaH / toluene / 45 - 50 °C 1.2: toluene / 1.5 h / Heating 2.1: NH2OH*HCl / ethanol / 1 h / Heating 3.1: LiAlH4 / diethyl ether / 0.5 h / 40 °C View Scheme
参考文献
Synthesis, , # 15 p. 2325 - 2330
参考文献
Cereda, Enzo; Ezhaya, Antoine; Quai, Monica; Barbaglia, Walter
Tetrahedron Letters, 2001 , vol. 42, # 30 p. 4951 - 4953
反应条件
1: formaldehyd; sulfuric acid; water / 6 h / |Reflux 2: sodium tetrahydroborate; isopropyl alcohol / 4 h View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 49, # 10 p. 1523 - 1533
Zh. Org. Khim., , vol. 49, # 10 p. 1543 - 1553,11
反应条件
(i) Mg, BrCH2CH2Br, Et2O, (ii) /BRN= 1209228/; Multistep reaction;
参考文献
Gazzetta Chimica Italiana, , vol. 99, p. 1107 - 1114
反应条件
thionyl chloride; sodium chloride in water; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6251926 B1, 2001 ;
反应条件
manganese(IV) oxide in chloroform T=20°C; 24 h; Cooling with ice;
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
