4-甲基-联苯-2-甲醛合成路线 （共 29 条）
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium hydroxide in neat (no solvent) T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueInert atmosphere; Reagent/catalyst;
参考文献
Asachenko, Andrey F.; Sorochkina, Kristina R.; Dzhevakov, Pavel B.; Topchiy, Maxim A.; Nechaev, Mikhail S.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3553 - 3557
反应条件
manganese (II) chloride in tetrahydrofuran 1 h; Heating;
参考文献
Goubet, Dominique; Meric, Pascal; Dormoy, Jean-Robert; Moreau, Patrice
Journal of Organic Chemistry, 1999 , vol. 64, # 12 p. 4516 - 4518
反应条件
1.1: n-BuLi / hexane / 1 h / 20 °C 1.2: 81 percent / hexane / 1 h / -78 °C 2.1: 90 percent / NaOH / PEG encapsulated palladium nanoparticle / H2O / 3.5 h / 90 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 18 p. 3639 - 3642
反应条件
pyridinium chlorochromate in dichloromethane T=25°C; 0.5 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: MnCl2 / tetrahydrofuran / 1 h / Heating 2: SiO2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 12 p. 4516 - 4518
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 4: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 5: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 11 percent / Cu / 1 h / 210 °C 2: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 3: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 11 percent / Cu / 1 h / 210 °C 2: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 3: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 2: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 3: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 88 percent / 4.5 N aq. HCl / 12 h / Heating 4: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 5: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 6: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
